Diphenoxylate

  • 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester
  • Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester
  • 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester
Formula
C30H32N2O2
Structure
Description
White crystalline powder with no odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
915-30-0
EC (EINECS/ELINCS)
213-020-1
RTECS
NS5290000
RTECS class
Drug
Merck
12,3371
Beilstein/Gmelin
503374
Beilstein Reference
5-22-02-00487
Austrailia AICS
Listed

Properties.
Formula
C30H32N2O2
Formula mass
452.6
Melting point, °C
220 - 225
Solubility in water
Slightly soluble.

Hazards and Protection.
Storage
Store in a tightly closed container. Use adequate ventilation.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Rubber gloves, safety goggles and appropriate laboratory clothing.
Respirators
NIOSH approved respirator.
Small spills/leaks
Wear an approved respirator and chemically compatible gloves. Vacuum/sweep up material. Avoid dust. Place material in an appropriate container for disposal.
Stability
Stable at normal temperatures and pressures.
Decomposition
Evolves hydrogen chloride and nitrogen oxides upon decomposition.

Fire.
Fire fighting
Evacuate area. Wear SCBA and protective clothing. Use water spray, dry chemical powder, carbon dioxide or foam as is appropriate for surrounding fire.
Fire potential
Combustible material.

Health.
Exposure effects
May cause morphine-like dependency. Anorexia, nausea, vomiting, headache, drowsiness, insomnia, dizziness, restlessness, euphoria, depression, numbness of the extremeties.
   Ingestion
See inhalation.
   Inhalation
Possible allergic reaction to dust if inhaled, inhaled. Causes irritation. Possible hypersensitization.
   Skin
May cause irritation.
   Eyes
May cause irritation.

First aid
 
   Ingestion
Wash mouth out with water. Obtain medical assistance.
   Inhalation
Move to fresh air. See medical aid. Give CPR and/or oxygen if necessary. Keep awake and warm. Walk around.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush with large amounts of water.

Transport.