Diphenylmethane-4,4'-diisocyanate

  • Methylene bisphenyl diisocyanate
  • 4,4-Diisocyanodiphenylmethane
  • Methylene bis(4-phenyl isocyanate)
  • MDI
Formula
C15H10N2O2
Structure
Description
White to pale yellow solid. May have slightly musty odor. Liquid above 38 deg c. Often shipped and stored in melted state for improved stability.
Uses
Adhesives, coatings manufacture, elastomers, flexible foam, rigid foam.

Registry Numbers and Inventories.
CAS
101-68-8
EC (EINECS/ELINCS)
202-966-0
EC Index Number
615-005-00-9
EC Class
Harmful; Irritant; Sensitising
R 20 36/37/38 42/43
S 23 36/37 45
RTECS
NQ9350000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2489
Beilstein/Gmelin
797662
Beilstein Reference
4-13-00-00396
Swiss Giftliste 1
G-3605
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C15H10N2O2
Formula mass
250.26
Melting point, °C
37 - 38
Boiling point, °C
373
Vapor pressure, mmHg
1E-5 (25 C)
Vapor density (air=1)
8.6
Saturation Concentration
0.18 ppm at 25 C (calculated)
Evaporization number
Extremely low
Critical temperature
578
Critical pressure
23.1
Density
1.318 g/cm3 (20 C)
Solubility in water
2 g/L (20 C)
Refractive index
1.5906 (50 C)
Partition coefficient, pKow
4.94
Heat of vaporization
62.1 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry place. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Refrigerator (approx 4 C).
D1A D2A D2B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water.
Disposal code
1
Stability
Stable under normal temperatures and pressures. Combines vigorously or explosively with water.
Incompatibilities
Alcohols, alkalies, acids.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, cyanide fumes, nitrogen.

Fire.
Flash Point,°C
154
Autoignition, °C
232
Lower exp. limit, %
0.6
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. May ignite or explode on contact with steam or moist air. Containers may explode when heated. Extinguishing media: Use dry sand or earth to smother fire. Use water spray to cool fire-exposed containers. DO NOT USE WATER! Most foams will react with the material and release corrosive/toxic gases. Contact professional fire-fighters immediately. Use dry chemical or carbon dioxide.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.
Combustion products
Toxic vapors are generated when heated.
Health
3
 
Flammability
1
 
 
Reactivity
1
 

Health.
Exposure limit(s)
OSHA PEL: C 0.2 mg/m3 (0.02 ppm) NIOSH REL: TWA 0.05 mg/m3 (0.005 ppm) C 0.2 mg/m3 (0.020 ppm) 10-minute NIOSH IDLH: 75 mg/m3
Poison_Class
3
Exposure effects
Prolonged or repeated skin contact may cause sensitization dermatitis and possible destruction and/or ulceration.
   Ingestion
Causes gastrointestinal tract irritation.
   Inhalation
Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause asthmatic attacks due to allergic sensitization of the respiratory tract.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation and possible burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2489
Response guide
Hazard class
6.1
USCG CHRIS Code
DPM
 
HS Code
2929 10 90
 
Std. Transport #
4966109
 
IMO Pollution Category
B
IMO Hazard code
S/P