Disulfiram

  • bis(Diethylthiocarbamoyl) disulfide
  • Tetraethylthiuram disulfide
  • Tetraethylthioperoxydicarbonic diamide
Formula
C10H20N2S4
Structure
Description
White or light gray, crystalline, slight odor.
Uses
alcohol aversive drug

Registry Numbers and Inventories.
CAS
97-77-8
EC (EINECS/ELINCS)
202-607-8
EC Index Number
006-079-00-8
EC Class
Harmful; Sensitising; Dangerous for the Environment
R 22 48/22 43 50/53
S 24 37 60 61
RTECS
JO1225000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
3077
Merck
13,3399
Beilstein/Gmelin
1712560
Beilstein Reference
4-04-00-00398
RCRA
U403
Swiss Giftliste 1
G-1595
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H20N2S4
Formula mass
296.54
Melting point, °C
70
Boiling point, °C
369
Vapor pressure, mmHg
1E-5 (25 C)
Density
1.34 g/cm3
Solubility in water
200 mg/L
Refractive index
1.6126 (84 C)
pKa/pKb
13.14 (pKb)
Partition coefficient, pKow
3.88
Heat of vaporization
61.6 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
177
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.

Health.
Exposure limit(s)
NIOSH REL: TWA 2 mg/m3
Poison_Class
3
Exposure effects
Increased respirations, elevated blood pressure, rapid heart rate and fever may occur. Abnormally low blood pressure may occur with severe overdose. Seizures and coma can be seen with overdose or ethanol interaction.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
3077
Response guide
HS Code
2930 30 00