Dodecyltrichlorosilane is a colorless to yellow liquid with a pungent odor.
Intermediate for silicones.
Registry Numbers and Inventories.
S 26 36/37/39 45
Japan ENCS (MITI)
Boiling point, °C
Vapor pressure, mmHg
0.004 (25 C)
1.03 g/cm3 (20 C)
Solubility in water
1.455 (20 C)
Partition coefficient, pKow
Heat of vaporization
Heat of combustion
Hazards and Protection.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear protective gloves and clothing and safety goggles.
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. Do not use water on material itself. Neutralize spilled material with crushed limestone, soda ash, or lime.
Keep away from oxidizing agents.
Use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.
Combustible material: may burn but does not ignite readily.
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.
Hydrochloric acid and phosgene fumes may form in fires.
Gastrointestinal tissue corrosion was observed in animals given single oral doses and may occur in humans following ingestion.
Cases of permanently disabling reactive airway syndrome have been reported in adults exposed for several hours to fumes of sodium hydroxide, trichlorosilane, and silicon tetrachloride.
The application of chlorosilanes to shaved rabbit skin produced various degrees of irritation. Complete denaturation and tissue sloughing occurred within one minute after exposure to dichlorodimethylsilane, within two to three minutes after exposure to methyltrichlorosilane, ethyltrichlorosilane, and dichlorodiethylsilane, and within 10 minutes after exposure to tetrachlorosilane.
May cause irritation.
If victim is conscious, give large amounts of water, then milk or milk of magnesia.
Remove from exposure; support respiration; call physician if needed.
Flush with water; obtain medical attention if skin is burned.
Flush with water for 15 min.; obtain medical attention immediately.
USCG CHRIS Code
Std. Transport #