Domperidone

  • 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
  • 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
  • KW-5338
  • Motilium
  • Peridon
Formula
C22H24ClN5O2
Structure
Description
White powder.
Uses
Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Registry Numbers and Inventories.
CAS
57808-66-9
EC (EINECS/ELINCS)
260-968-7
RTECS
DE2275900
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,3476
Beilstein/Gmelin
903774
Beilstein Reference
5-24-02-00402
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C22H24ClN5O2
Formula mass
425.92
Melting point, °C
236 - 239
Solubility in water
Insoluble
pKa/pKb
4.80 (pKb)

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
-
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Possible risk of harm to the unborn child. Possible risk of impaired fertility. Target organ(s): G.I. System.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.