Doxorubicin hydrochloride

  • Adriblastina RD
  • Lipodox
  • Adriamycin
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
Formula
C27H29NO11.ClH
Structure
Description
Orange-red thin needles.
Uses
chemotherapeutic agent for the management of a variety of neoplasms

Registry Numbers and Inventories.
CAS
25316-40-9
EC (EINECS/ELINCS)
246-818-3
RTECS
QI9295900
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
4229251
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C27H29NO11*ClH
Formula mass
580.03
Melting point, °C
204
Decomposition point, °C
204-205
Partition coefficient, pKow
-0.8

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This compound is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Human fatalities have been reported from acute poisoning.
   Inhalation
Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema.
   Skin
Causes skin irritation. May cause an allergic reaction in certain individuals.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.