Doxorubicin

  • ADM
  • Adriamycin
  • Adriblastin
  • Adriblastina
  • (85-Cis)-10
  • Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-methoxy-5,12-Naphthacenedione
Formula
C27H29NO11
Structure
Description
Orange powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
23214-92-8
EC (EINECS/ELINCS)
245-495-6
RTECS
AV9800000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant
Merck
12,3495
Beilstein/Gmelin
1445811
Canada DSL/NDSL
DSL
New Zealand
Listed

Properties.
Formula
C27H29NO11
Formula mass
543.53
Melting point, °C
216
Solubility in water
2%
pKa/pKb
8.33 (pKa)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
I-2A, N-2, CP65
Exposure effects
Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals.
   Ingestion
Nausea, vomiting, and diarrhea may occur.
   Inhalation
Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema.
   Skin
Doxorubicin has irritant properties. Severe ulceration and necrosis may occur from extravasation.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.