Doxycycline

  • Doxycyclin hyclate
  • alpha-6-Deoxy-5-hydroxytetracycline
  • 6-Deoxy-5-hydroxytetracycline
  • alpha-6-Deoxyoxytetracycline
  • alpha-6-Deoxyoxytetracycline monohydrate
  • 6-Deoxytetracycline
Formula
C22H24N2O8.H2O
Structure
Description
Yellow, crystalline powder with slight ethanolic odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
564-25-0
EC (EINECS/ELINCS)
209-271-1
RTECS
QI8650000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,3496
Beilstein/Gmelin
2230419
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C22H24N2O8
Formula mass
444.44
Vapor pressure, mmHg
2E-24 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
4.50 (pKa)
Partition coefficient, pKow
-0.26

Hazards and Protection.
Storage
store in a tightly closed container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Rubber or vinyl gloves, safety goggles and appropriate laboratory clothings.
Respirators
NIOSH approved respirator.
Small spills/leaks
Wear dust respirator and rubber gloves. Sweep up, avoiding dust generation. Place in appropriate container for disposal.
Stability
Stable at normal temperatures and pressures.
Decomposition
Toxic fumes.

Fire.
Fire fighting
Evacuate area. Wear SCBA and protective clothing. Use agent most suitable for extinguishing surrounding fire.

Health.
Exposure effects
Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy.
   Ingestion
Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon.
   Inhalation
Allergic reaction. Irritation.
   Skin
Skin hyperpigmentation has been reported.
   Eyes
Irritation.

First aid
 
   Ingestion
Flush mouth out with water. Seek medical attention.
   Inhalation
Remove to fresh air.
   Skin
Flush with copious amounts of water for at least 15 minutes.
   Eyes
Flush with copious amounts of water for at least 15 minutes.

Transport.