Emetine

  • Cephaeline methyl ether
  • Cephaline-o-methyl ether
  • Emetin
  • (-)-Emetine
  • Methyl cephaeline
  • 6',7',10,11-Tetramethoxyemetan
Formula
C29H40N2O4
Structure
Description
White amorphous powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
483-18-1
EC (EINECS/ELINCS)
207-592-1
RTECS
DK1750000
RTECS class
Tumorigen; Drug; Mutagen; Human Data; Natural Product; Primary Irritant
Merck
12,3600
Beilstein/Gmelin
100829

Properties.
Formula
C29H40N2O4
Formula mass
480.65
Melting point, °C
74
Solubility in water
Insoluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Turns yellow on exposure to light and heat. Solid and solutions turn yellow on exposure to light or heat. Emetine dihydrochloride darkens on exposure to light.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Rapid heart rate and abnormally low blood pressure may be seen with large doses or chronic abuse. With therapeutic use - 1. Rapid heart rate and abnormally low blood pressure may be seen with large doses.
   Ingestion
Acute ingestion of the fluid extract results in protracted vomiting, abdominal cramps, and profuse diarrhea.
   Eyes
Eye contact causes delayed irritation and superficial corneal injury.

First aid
 
   Ingestion
Do not administer additional syrup of ipecac since emesis is the toxic effect. Do not administer a cathartic. Activated charcoal is unlikely to be of use. Treat dehydration with intravenous or oral fluids.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.