Endothion

  • O,O-Dimethyl S-(5-methoxy-4-oxo-4h-pyran-2-yl) phosphorothioate
  • O,O-Dimethyl S-(5-methoxypyronyl-2-methyl) thiophosphate
  • 5-Methoxy-2-(dimethoxyphosphinylthiomethyl) pyrone-4
  • S-((5-Methoxy-4-oxo-4H-Pyran-2-yl)methyl) O,O-dimethyl phosphorothioate
  • S-5-methoxy-4-oxopyran-2-ylmethyl dimethyl phosphorothioate
  • S-(5-methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothioate
Formula
C9H13O6PS
Structure
Description
White crystals with a slight odor. Not sold in the USA or Canada.
Uses
Systemic aphicide, acaricide.

Registry Numbers and Inventories.
CAS
2778-04-3
EC (EINECS/ELINCS)
220-472-3
EC Index Number
015-049-00-3
EC Class
Toxic
RTECS
TF8225000
RTECS class
Agricultural Chemical and Pesticide
UN (DOT)
2783
Beilstein/Gmelin
252435
Beilstein Reference
4-18-00-01160
EPA OPP
422100
Swiss Giftliste 1
G-1612

Properties.
Formula
C9H13O6PS
Formula mass
280.25
Melting point, °C
74 - 76
Solubility in water
150 g/100 ml @ 20 C

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate clothing to prevent any reasonable probability of skin contact. Wear eye protection to prevent any possibility of eye contact.
Respirators
Escape: any gas mask providing protection against organic vapors and particulates; any escape self-contained breathing apparatus.
Small spills/leaks
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry containers and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal.
Stability
No data.

Fire.
Fire fighting
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Stay upwind; keep out of low areas. Move containers from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Wear positive pressure breathing apparatus and special protective clothing.(Non-Specific -- Organophosphorus Pesticide, n.o.s.) This material may burn, but does not ignite readily. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam.
Fire potential
Non-Combustible
Hazards
Cylinder may explode in heat or fire. Fire and runoff from fire control water may produce irritating or poisonous gases. When heated to decomposition, it emits very toxic fumes of phosphorous oxides and sulfur oxides.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
2
Exposure effects
Fever, low heart rate and abnormally low blood pressure, or rapid heart rate and elevated blood pressure may occur. Headache, dizziness, muscle spasms and profound weakness are common. Alterations of level of consciousness, anxiety, paralysis, seizures and coma may occur. Seizures may be more common in children.
   Ingestion
Vomiting, hypersalivation, diarrhea, fecal incontinence and abdominal pain may occur.
   Inhalation
Dyspnea, rales, bronchorrhea, bronchospasm, or tachypnea may be noted. Noncardiogenic pulmonary edema may occur in severe cases. Chemical pneumonitis may be seen.
   Skin
Sweating is a consistent but not universal sign.
   Eyes
Constriction of the pupil, tearing, and blurred vision are common. Prolonged dialation of the pupils may occur in severe poisonings. Opsoclonus has been reported in one case. Salivation commonly occurs.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Systemic effects can occur from dermal exposure to organophosphates. Remove contaminated clothing, wash skin, hair and nails vigorously with repeated soap washings. Leather absorbs pesticides; all contaminated leather should be discarded. Rescue personnel and bystanders should avoid direct contact with contaminated skin, clothing, or other objects. Treatment should include recommendations listed in the oral exposure section when appropriate. Some chemicals can produce systemic poisoning by absorption through intact skin. Carefully observe patients with dermal exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary. Contraindications - succinylcholine and other cholinergic agents are contraindicated.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved. Suction oral secretions until atropinization. Treatment should include recommendations listed in the oral exposure section when appropriate. Contraindications - succinylcholine and other cholinergic agents are contraindicated.

Transport.
UN number
2783
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
ENT