Enflurane

  • Ethrane
  • 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
  • 2-Chloro-1-(difluoromethoxy)-1,1,2-Trifluoroethane
Formula
CHF2OCF2CHClF
Structure
Description
Clear, colorless liquid with a mild, sweet odor.
Uses
Induction and maintenance of general anaesthesia.

Registry Numbers and Inventories.
CAS
13838-16-9
EC (EINECS/ELINCS)
237-553-4
RTECS
KN6800000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
13,3615
Beilstein/Gmelin
1903921
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C3H2ClF5O
Formula mass
184.49
Boiling point, °C
56.5
Vapor pressure, mmHg
175 (25 C)
Vapor density (air=1)
>1
Density
1.5167 g/cm3 (25 C)
Solubility in water
Slightly soluble
Refractive index
1.3025 (20 C)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Safety goggles.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure limit(s)
TLV: 75 ppm; 566 mg/m3 (as TWA) A4 (ACGIH 1997). NIOSH REL: C 2 ppm (15.1 mg/m3) 60-minute *Note: REL for exposure to waste anesthetic gas.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Acute effects - drowsiness, unconsciousness, weakness. Mayu cause effects on the liver at narcotic concentrations. Could cause lowering of consciousness.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.