(-)-Ephedrine sulfate

  • Isofedrol
  • (1R,2S)-1-Phenyl-2-methylaminopropanol-1 sulfate
  • (-)-erythro-1-Hydroxy-2-(methylamino)-1-phenylpropane sulfate
  • Benzenemethanol, a-[1-(methylamino)ethyl]-, [R-(R*,S*)]-, sulfate (2:1)
Formula
(C10H15NO)2.H2O4S
Structure
Description
White crystals.
Uses
Bronchodilator.

Registry Numbers and Inventories.
CAS
134-72-5
EC (EINECS/ELINCS)
205-154-4
RTECS
KB2625000
RTECS class
Tumorigen; Drug; Mutagen; Human Data
Beilstein/Gmelin
3775735
Beilstein Reference
4-13-00-01879
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed

Properties.
Formula
2C10H15NO*H2O4S
Formula mass
428.60
Melting point, °C
257
Solubility in water
1 g/ml

Hazards and Protection.
Storage
Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. Light sensitive.
Incompatibilities
Direct light, strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Harmful if swallowed. May cause central nervous system effects. May cause increase in blood pressure.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.