Epirizole

  • Mepirizole
  • 1-(4'-Methoxy-6'-methyl-2'-pyrimidinyl)-3-methyl-5-methoxypyrazole
  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
  • 1-(4-Methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole
  • 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine
Formula
C11H14N4O2
Structure
Uses
A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.

Registry Numbers and Inventories.
CAS
18694-40-1
EC (EINECS/ELINCS)
242-507-1
20/21/22 36/37/38
RTECS
UV9290000
RTECS class
Drug
Merck
12,3659
Beilstein/Gmelin
751084
Beilstein Reference
5-25-18-00012
Japan ENCS (MITI)
Listed

Properties.
Formula
C11H14N4O2
Formula mass
234.26
Melting point, °C
90 - 92
Boiling point, °C
444
Vapor pressure, mmHg
4E-8 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.35 (pKb)
Heat of vaporization
70.2 kJ/mol

Hazards and Protection.
Storage
Store at 2 - 8 C.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
222
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.