Ergonovine

  • Ergoatetrine
  • Ergobasine
  • N-[1-(Hydroxymethyl)ethyl]-D-lysergamide
  • 9,10-Dihydro-n-(a-(hydroxymethyl)ethyl)-6-methylergoline-8-b-carboxamide
Formula
C19H23N3O2
Structure
Description
Tetrahedra from ethyl acetate, fine needles from benzene; tends to form
Uses
Medication.

Registry Numbers and Inventories.
CAS
60-79-7
EC (EINECS/ELINCS)
200-485-0
RTECS
KE5075000
RTECS class
Human Data; Natural Product
Merck
12,3694
Beilstein/Gmelin
94899
Beilstein Reference
4-25-00-00950
Austrailia AICS
Listed

Properties.
Formula
C19H23N3O2
Formula mass
325.41
Melting point, °C
195
Solubility in water
Slightly soluble
pKa/pKb
6.70 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Headache, coma, seizures, vertigo, psychotic disturbance, and slurring of speech may occur.
   Ingestion
Vomiting, diarrhea, and abdominal cramps may occur.

First aid
 
   Ingestion
Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Vasoconstriction and hypertension - nitroprusside is recommended to reverse peripheral ischemia secondary to vasoconstriction and for the treatment of hypertension. Administer 1 to 2 mcg/kg/min iv while monitoring vital signs regularly. Usual dose would be 200 to 500 mcg/minute. Anticoagulant therapy with intravenous heparin should also be considered in patients with evidence of ischemia.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.