Ergotamine tartrate

  • Gotamine tartrate
  • Gynergen
  • Secagyn
  • Rigetamin
  • 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3',6',18-trione deriv.
  • Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt)
Formula
(C33H35N5O5)2.C4H6O6
Structure
Description
Powder or liquid forms available as drugs.
Uses
Used in obstetrics and in the treatment of migraine headaches.

Registry Numbers and Inventories.
CAS
379-79-3
EC (EINECS/ELINCS)
206-835-9
RTECS
KE8225000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
6173437
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C33H35N5O5*C4H6O6*2H2O
Formula mass
1313.56
Melting point, °C
203
Decomposition point, °C
202
Density
1.511 g/cm3

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
(Non-Specific -- Alkaloid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do so without risk. Use water vapor to reduce vapors. Absorb spills with sand or other noncombustible absorbent material. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. For large spills, dike far ahead of spill for later disposal.
Stability
No data.
Incompatibilities
Sensitive to prolonged exposure to heat and light.

Fire.
Fire fighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Hazards
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Protect from light and heat

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.
USCG CHRIS Code
ETT