Erythromycin

  • Abboticin
  • Abomacetin
  • Dotycin
  • EMU
  • Erycin
  • Erycinum
Formula
C37H67NO13
Structure
Description
Hydrated crystals from water. Odorless or practically odorless.
Uses
pharmaceutical

Registry Numbers and Inventories.
CAS
114-07-8
EC (EINECS/ELINCS)
204-040-1
RTECS
KF4375000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
Merck
12,3720
Beilstein/Gmelin
75279
Beilstein Reference
5-18-10-00398
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C37H67NO13
Formula mass
733.94
Melting point, °C
135-140
Density
1.226 g/cm3
Solubility in water
about 2 mg/ml
pKa/pKb
8.8 (pKb)

Hazards and Protection.
Storage
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Vital sign changes, while rare, may include reduced body temperature and abnormally low blood pressure. sensorineural hearing loss may occur in patients receiving treatment with large doses of macrolide antibiotics, especially in patients suffering from concomitant liver and/or kidney disease. The hearing loss is usually reversible upon discontinuation of the drug. Exacerbation of myasthenia gravis may occur infrequently following erythromycin administration. Pyloric stenosis has been associated with the ingestion of erythromycin through breastmilk.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Substance may cause liver and blood abnormalities. Allergic reactions and hearing abnormalities have also been
   Inhalation
May cause allergic respiratory reaction.
   Skin
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.