Estramustine

  • Estradiol, 3-(bis(2-chloroethyl)carbamate)
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate) (9CI)
  • LEO 275
  • Estradiol 3-[N,N-bis(2-chloroethyl)carbamate]
  • Estracty
Formula
C23H31Cl2NO3
Structure
Uses
Antineoplastic.

Registry Numbers and Inventories.
CAS
2998-57-4
EC (EINECS/ELINCS)
221-076-3
RTECS
KG4250000
Merck
12,3749

Properties.
Formula
C23H31Cl2NO3
Formula mass
440.41
Melting point, °C
104 - 105
Vapor pressure, mmHg
1.2E-13 (25 C)
Density
1.253 g/cm3
Solubility in water
Insoluble
pKa/pKb
15.05 (pKa)
Partition coefficient, pKow
5.35

Hazards and Protection.
Storage
Store in original container in a cool dark place.
Protection
Protective work clothing. Chemical protective gloves. Safety glasses or goggles.
Small spills/leaks
Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Fire.
Fire fighting
Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes
Combustion products
Emits toxic fumes under fire conditions.

Health.
Exposure effects

First aid
 
   Ingestion
If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
   Inhalation
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
   Skin
Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
   Eyes
Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Transport.