Estrone

  • 1,3,5(10)-Estratrien-3-ol-17-one
  • 3-Hydroxyestra-1,3,5(10)-trien-17-one
  • Endofolliculina
  • Follicular hormone
  • Ketohydroxyestrin
  • Oestrone
Formula
C18H22O2
Structure
Description
Small, white crystals, or white to creamy white, crystalline powder. Odorless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
53-16-7
EC (EINECS/ELINCS)
200-164-5
RTECS
KG8575000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone; Natural Product
UN (DOT)
1325
Merck
12,3751
Beilstein/Gmelin
1915077
Beilstein Reference
3-08-00-01171
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C18H22O2
Formula mass
270.37
Melting point, °C
264 - 264.5
Boiling point, °C
292
Critical temperature
607
Critical pressure
24.8
Density
1.238 g/cm3
Solubility in water
Insoluble
pKa/pKb
10.34 (pKa)
Partition coefficient, pKow
3.13

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam. Use agent most appropriate to extinguish fire.
Fire potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Exposure limit(s)
OSHA: Possible Select carcinogen
Carcinogin
I-1, N-2, CP65
Exposure effects
headache, vertigo, excessive thirst, and hypersensitivity reactions have been noted. Maternal ingestion of DES during early pregnancy increases the risk of vaginal adenocarcinoma and the incidence of epididymal cysts, maldescended testes, hypoplastic testes, varicoceles, spermatozoal defects and perhaps seminoma in the exposed offspring many years later. <br>Masculinization of the female fetus may occur during the first trimester.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause headache, nausea, fatigue, and dizziness. May cause discomfort in breasts and weight gain.
   Inhalation
Inhalation of dust may cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III