Etacrynic acid

  • Etakrinic acid
  • Hydromedin
  • Taladren
  • [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid
  • [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid
  • 2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid
Formula
C13H12Cl2O4
Structure
Description
White solid.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
58-54-8
EC (EINECS/ELINCS)
200-384-1
RTECS
AG6600000
RTECS class
Drug; Human Data
Merck
12,3761
Beilstein/Gmelin
1915060
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C13H12Cl2O4
Formula mass
303.14
Melting point, °C
122.2
Solubility in water
Soluble
pKa/pKb
2.80 (pKa)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
May react vigorously with strong oxidizing agents Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen May react exothermically with acids Reacts exothermically with all bases both organic (for example, the amines) and inorganic.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide ot Halon extinguisher.
Fire potential
This chemical is probably combustible.

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms associated with exposure to this chemical may include fluid and electrolyte imbalances, gout, gastrointestinal disturbances, depression of formed elements of the blood, skin rashes, paresthesias and hepatic dysfunction. It may also cause transient or permanent deafness in rare cases.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.