Ethyl 2-acetyl-3-methylbutanoate

  • 2-Acetyl-3-methylbutyric acid ethyl ester
  • 2-Isopropyl-3-oxobutanoic acid ethyl ester
  • Ethyl 2-isopropylacetoacetate
  • Ethyl a-isopropylacetoacetate
  • Butanoic acid, 2-acetyl-3-methyl-, ethyl ester
  • Acetoacetic acid, 2-isopropyl-, ethyl ester
Formula
C9H16O3
Structure
Description
Clear, colorless liquid.

Registry Numbers and Inventories.
CAS
1522-46-9
EC (EINECS/ELINCS)
216-192-6
23 24/25
Beilstein/Gmelin
636360
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H16O3
Formula mass
172.22
Melting point, °C
-20
Boiling point, °C
201
Vapor pressure, mmHg
0.03 (25 C)
Critical temperature
380
Critical pressure
24.72
Density
0.962 g/cm3 (20 C)
Solubility in water
3.9 g/L (25 C)
Refractive index
1.425 (20 C)
pKa/pKb
12.28 (pKa)
Partition coefficient, pKow
1.94
Heat of vaporization
44.34 kJ/mol

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.
Small spills/leaks
Ventilate area and wash spill site after material pickup is complete. Absorb on sand or vermiculite and place in closed containers for disposal. Wash spill site with soap solution. Flush spill area with copious amounts of water.

Fire.
Flash Point,°C
76
Fire fighting
For small (incipient) fires, use media such as alcohol foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.