Ethyl 4-chloroacetoacetate

  • Ethyl 4-chloro-3-oxobutanoate
  • Ethyl 4-chloro-3-oxobutyrate
  • Ethyl g-chloroacetoacetate
  • Ethyl (chloroacetyl)acetate
  • 4-Chloro-3-oxobutanoic acid ethyl ester
  • Butanoic acid, 4-chloro-3-oxo-, ethyl ester
Formula
ClCH2COCH2COOC2H5
Structure
Description
Clear colorless to pale yellow red liquid. Acetic odor.

Registry Numbers and Inventories.
CAS
638-07-3
EC (EINECS/ELINCS)
211-317-0
EC Class
toxic, corrosive, sensitizing, dangerous for the environment
R 24/25 36/37/38
S 26 36/37/39 45
RTECS
AK5110000
RTECS class
Other
UN (DOT)
2810
Beilstein/Gmelin
1761275
Beilstein Reference
4-03-00-01550
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C6H9ClO3
Formula mass
164.59
Melting point, °C
-8
Boiling point, °C
236
Vapor pressure, mmHg
0.05 (25 C)
Vapor density (air=1)
5.68
Density
1.21 g/cm3
Solubility in water
Slightly soluble
Refractive index
1.4221 (19 C)
pKa/pKb
9.56 (pKa)
Partition coefficient, pKow
1.67
Heat of vaporization
47.2 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Disposal code
2
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong acids, strong bases, strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
97
Autoignition, °C
320
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Effects may be delayed.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
   Skin
Causes skin irritation.
   Eyes
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2918 30 00