Ethylene glycol monomethyl ether

  • 2-Methoxyethanol
  • Methyl cellosolve
Formula
CH3OCH2CH2OH
Structure
Description
Clear, colorless liquid with a mild ethereal odor.
Uses
Solvent for low viscosity cellulose acetate, natural resins, some synthetic resins & some alc sol dyes, in dyeing leather, in modified karl fischer reagent, in sealing moistureproof cellophane, in quick drying varnishes, enamels, nail polishes, wood stains.

Registry Numbers and Inventories.
CAS
109-86-4
EC (EINECS/ELINCS)
203-713-7
EC Index Number
603-011-00-4
EC Class
Flammable; Toxic for reproduction Category 2; Harmful
R 60 61 10 20/21/22
RTECS
KL5775000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
1188
Merck
12,6118
Beilstein/Gmelin
1731074
Beilstein Reference
4-01-00-02375
EPA OPP
42202
Swiss Giftliste 1
G-1181
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H8O2
Formula mass
76.10
Melting point, °C
-85
Boiling point, °C
124.6
Vapor pressure, mmHg
6.2 (20 C)
Vapor density (air=1)
2.62
Saturation Concentration
0.82% at 20 C
Evaporization number
34 (diethyl ether = 1)
Odor Threshold Odor threshold 60 ppm
Critical temperature
324
Critical pressure
52.16
Density
0.98235 g/cm3 (0 C)
Solubility in water
Miscible
Viscosity
1.53 cp (25 C)
Surface tension
0.033 n/m @ 20 C
Refractive index
1.4028 (20 C)
Dipole moment
2.36 D
Dielectric constant
15.4 (20 C)
Partition coefficient, pKow
-0.77
Heat of vaporization
37.5 kJ/mol
Heat of combustion
-167 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
B3 D1B D2A D2B
Handling
Wash thoroughly after handling. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure, rubber or neoprene gloves.
Respirators
A half-face organic vapor respirator may be worn for up to ten times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece organic vapor respirator may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Remove all sources of ignition. Use a spark-proof tool. A vapor suppressing foam may be used to reduce vapors.
Disposal code
1
Stability
Stable under ordinary conditions of use and storage. Formation of explosive peroxides has been reported from auto-oxidation
Incompatibilities
Strong oxidizing agents, alkalis and acids.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
39
Autoignition, °C
286
Upper exp. limit, %
14
Lower exp. limit, %
1.8
Fire fighting
Wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide.
Fire potential
Flamable liquid and vapor. May form explosive peroxides in air.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Combustion products
Toxic gases and vapor (such as carbon monoxide) may be released in a fire involving methyl cellosolve.
Health
2
 
Flammability
2
 
 
Reactivity
2
 

Health.
Exposure limit(s)
OSHA PEL: TWA 25 ppm (80 mg/m3) skin NIOSH REL: TWA 0.1 ppm (0.3 mg/m3) skin NIOSH IDLH: 200 ppm
Poison_Class
2
Exposure effects
Prolonged exposure may cause injury to bone marrow, blood cells, kidney, liver and testes. A suspected human reproductive hazard and a birth defect hazard. Severe neurological disabilities has been reported from chronic industrial exposure. Symptoms have included headache, dizziness, lethargy, weakness, personality changes, apathy, unequal pupil size, and disorientation.
   Ingestion
Moderately toxic. Can cause headache, fatigue, nausea, vomiting, dizziness, and weakness. Hemorrhagic gastritis, liver damage, pancreas damage and brain edema resulting in death has occurred in human exposure of 3 g/kg. Damage to kidneys is possible from ingestion of large quantities.
   Inhalation
Inhalation of vapors may cause irritation, headache, dizziness, fatigue, nausea, vomiting, and loss of appetite. Weakness, incoordination and tremors may occur.
   Skin
May cause irritation with redness and pain. May be absorbed through the skin with possible systemic effects.
   Eyes
May cause irritation, redness and pain.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1188
Response guide
Hazard class
3
Packing Group
III
 
USCG CHRIS Code
EME
 
40 Glycol ethers
HS Code
2909 42 00
 
Std. Transport #
4912062 4912222
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S