Etofylline

  • Soluphylline
  • Oxyethyltheophylline
  • Hydroxyethyltheophylline
  • 7-(2-Hydroxyethyl)-1,3-dimethylxanthine
  • 7-(b-Hydroxyethyl)theophylline
  • 1,3-Dimethyl-7-(2-hydroxyethyl)xanthine
Formula
C9H12N4O3
Structure
Description
White powder.
Uses
Intermediate in the preparation of 7-substituted xanthines

Registry Numbers and Inventories.
CAS
519-37-9
EC (EINECS/ELINCS)
208-269-8
RTECS
XH5850000
RTECS class
Drug; Reproductive Effector
Merck
12,3924
Beilstein/Gmelin
251760
Beilstein Reference
5-26-14-00038
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H12N4O3
Formula mass
224.22
Boiling point, °C
496
Vapor pressure, mmHg
1E-10 (25 C)
Solubility in water
Soluble
pKa/pKb
13.39 (pKb)
Heat of vaporization
80.4 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Stability
Stable at normal temperatures and pressures.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
254
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful if swallowed.
   Ingestion
Harmful if swallowed.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.