Fenretinide

  • Retinoic acid-p-hydroxyphenylamide
  • N-(4-Hydroxyphenyl)retinamide
Formula
C26H33NO2
Structure
Description
Orange solid, packaged under an inert gas.
Uses
A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.

Registry Numbers and Inventories.
CAS
65646-68-6
RTECS
VH6420000
Merck
12,4040
Beilstein/Gmelin
5769490

Properties.
Formula
C26H33NO2
Formula mass
391.55
Melting point, °C
178 - 181
Vapor pressure, mmHg
7.1E-15 (25 C)
Density
1.08 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
9.98 (pKa)
Partition coefficient, pKow
7.41

Hazards and Protection.
Storage
Freezer (-20 C). Protect from light. This product is stable for 3 years as supplied.

Fire.

Health.
Exposure effects

First aid
 

Transport.