- Retinoic acid-p-hydroxyphenylamide
Orange solid, packaged under an inert gas.
A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
Registry Numbers and Inventories.
Melting point, °C
178 - 181
Vapor pressure, mmHg
7.1E-15 (25 C)
1.08 g/cm3 (20 C)
Solubility in water
Partition coefficient, pKow
Hazards and Protection.
Freezer (-20 C). Protect from light. This product is stable for 3 years as supplied.