Fluocinolone acetonide

  • 6a,9a-Difluoro-16a-hydroxyprednisolone 16,17-acetonide
  • Sinalar
  • 6a-Fluorotriamcinolone acetonide
  • Synandone
Formula
C24H30F2O6
Structure
Uses
A synthetic steroid used as an anti-inflammatory and anti-pruritic agent.

Registry Numbers and Inventories.
CAS
67-73-2
EC (EINECS/ELINCS)
200-668-5
20/21/22 36/37/38 40
22 26 36
RTECS
TU3830000
RTECS class
Drug; Mutagen; Reproductive Effector
Merck
12,4185
Beilstein/Gmelin
1358395
Beilstein Reference
5-19-06-00571
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C24H30F2O6
Formula mass
452.5
Melting point, °C
267 - 269
Boiling point, °C
579
Vapor pressure, mmHg
9E-16 (25 C)
Solubility in water
Insoluble
pKa/pKb
12.55 (pKa)
Heat of vaporization
99.4 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Evacuate area. Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Wear disposable coveralls and discard them after use.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Fire.
Flash Point,°C
304
Fire fighting
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Limited evidence of a carcinogenic effect Possible teratogen. Possible mutagen.
   Ingestion
Harmful/toxic if swallowed
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.
   Skin
Causes irritation. Toxic if absorbed through the skin.
   Eyes
Causes irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen

Transport.