Fluocinonide

  • Fluocinolide acetate
  • Dermaplus
  • Metosyn
  • Topsyn
  • Fluocinolone acetonide 21-acetate
  • Pregna-1,4-diene-3,20-dione, 6a,9-difluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal
Formula
C26H32F2O7
Structure
Uses
Used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions.

Registry Numbers and Inventories.
CAS
356-12-7
EC (EINECS/ELINCS)
206-597-6
22 25 36/37/39 45
RTECS
TU3831000
RTECS class
Drug; Mutagen; Reproductive Effector; Hormone
UN (DOT)
2811
Merck
12,4186
Beilstein/Gmelin
4772994
Beilstein Reference
6-19
Canada DSL/NDSL
DSL
Austrailia AICS
Listed

Properties.
Formula
C26H32F2O7
Formula mass
494.53
Vapor pressure, mmHg
2E-16 (25 C)
Solubility in water
Insoluble
pKa/pKb
11.83 (pKa)
Heat of vaporization
101.2 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Fire.
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Very toxic if swallowed. Possible risk of harm to the unborn child. Readily absorbed through skin.
   Ingestion
May be fatal if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin. Readily absorbed through skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
II