Fluoxetine

  • Prozac
  • Deprex
  • Fluval
  • 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
  • N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine
  • dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Formula
C17H18F3NO
Structure
Uses
Medication.

Registry Numbers and Inventories.
CAS
54910-89-3
RTECS
DA8326855
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,4222
Beilstein/Gmelin
3991406

Properties.
Formula
C17H18F3NO
Formula mass
309.33
Melting point, °C
158
Solubility in water
Insoluble
pKa/pKb
3.95 (pKb)
Partition coefficient, pKow
3.749

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
overdose effects, in most patients, include only mild neurological symptoms. However, seizures and coma may occur. Therapeutic doses have been reported to cause dizziness, tremor, restlessness, ataxia, and syncope. Serotonin syndrome may develop after overdose or when used therapeutically with other serotonergic agents. Fluoxetine has no known teratogenic effect in humans; US FDA pregnancy category C.
   Ingestion
Nausea, vomiting, and diarrhea have all been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.