Flutamide

  • Niftholide
  • 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
  • 4'-Nitro-3'-trifluoromethylisobutyranilide
  • N-(Isopropylcarbonyl)-4-nitro-3-trifluoromethylaniline
Formula
C11H11F3N2O3
Structure
Uses
Non-steroidal anti-androgen.

Registry Numbers and Inventories.
CAS
13311-84-7
EC (EINECS/ELINCS)
236-341-9
20/21/22 63
RTECS
UG5700000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,4242
Beilstein/Gmelin
2157663
Beilstein Reference
6-12
Canada DSL/NDSL
DSL

Properties.
Formula
C11H11F3N2O3
Formula mass
276.22
Melting point, °C
110 - 111
Boiling point, °C
400
Vapor pressure, mmHg
1E-6 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.12 (pKa)
Heat of vaporization
65.1 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen fluoride.

Fire.
Flash Point,°C
196
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful. Possible risk of harm to the unborn child. Harmful by inhalation, in contact with skin and if swallowed. Target organ(s): Male reproductive system. Possible carcinogen. Calif. Prop. 65 reproductive hazard.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.