Frangulic acid

  • Emodin
  • Rheum emodin
  • 3-Methyl-1,6,8-trihydroxyanthraquinone
  • 1,3,8-Trihydroxy-6-methylanthraquinone
  • 4,5,7-Trihydroxy-2-methylanthraquinone
  • 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione
Formula
C15H10O5
Structure
Description
Orange needles or powder.
Uses
Formerly used as a laxative.

Registry Numbers and Inventories.
CAS
518-82-1
EC (EINECS/ELINCS)
208-258-8
RTECS
CB7920600
RTECS class
Tumorigen; Mutagen
Merck
12,3602
Beilstein/Gmelin
1888141
Beilstein Reference
4-08-00-03575
Korea ECL
Listed

Properties.
Formula
C15H10O5
Formula mass
270.24
Melting point, °C
263
Boiling point, °C
529
Vapor pressure, mmHg
1E-11 (25 C)
Solubility in water
Insoluble
pKa/pKb
6.39 (pKa)
Partition coefficient, pKow
4.35
Heat of vaporization
83.4 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Flash Point,°C
288
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.