Fumagillin

  • Amebacillin
  • 2,4,6,8-Decatetraenedioic acid, mono[4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro[2.5]oct-6-yl] ester
  • 2,4,6,8-Decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1- oxaspiro(2,5)oct-6-yl ester
Formula
C26H34O7
Structure
Description
White powder.
Uses
Inhibitor of endothelial cell proliferation and angiogenesis.

Registry Numbers and Inventories.
CAS
23110-15-8
EC (EINECS/ELINCS)
245-433-8
RTECS
HE1750000
RTECS class
Drug; Reproductive Effector
Merck
12,4308
Beilstein/Gmelin
1300222
Beilstein Reference
5-19
Canada DSL/NDSL
DSL
New Zealand
Listed

Properties.
Formula
C26H34O7
Formula mass
458.55
Melting point, °C
192 - 194
Vapor pressure, mmHg
3E-16 (25 C)
Solubility in water
Insoluble
pKa/pKb
4.41 (pKa)
Heat of vaporization
98.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in the dark. Store with desiccant. Store at -20 C
Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures. Sensitive to moisture. Sensitive to light.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
199
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
-
 
Flammability
0
 
 
Reactivity
1
 

Health.
Exposure effects
Harmful. Harmful if swallowed.
   Ingestion
Harmful if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.