Furosemide

  • Aluzine
  • 4-Chloro-n-(2-furylmethyl)-5-sulfanoylanthranilic acid
  • Beronald
  • 4-Chloro-n-furfuryl-5-sulfamoylanthranilic acid
Formula
C12H11ClN2O5S
Structure
Description
Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
54-31-9
EC (EINECS/ELINCS)
200-203-6
RTECS
CB2625000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,4331
Beilstein/Gmelin
840915
Beilstein Reference
5-18-09-00555
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H11ClN2O5S
Formula mass
330.75
Melting point, °C
206
Decomposition point, °C
220
Solubility in water
slightly soluble
pKa/pKb
3.9 (pKa)
Partition coefficient, pKow
2.56

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Unstable in light but stable in air.
Incompatibilities
Incompatible with strong oxidizing agents.

Fire.
Fire fighting
Fires involving this material can be controlled with a carbon dioxide, dry chemical or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.
   Inhalation
Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.