Gadoteridol

  • Gadolinium HP DO3A
  • 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclo- dodecane-1,4,7-triacetic acid, monogadolinium salt
  • GD HP DO 3A
  • Prohance
  • SQ-32692
Formula
C17H29GdN4O7
Structure
Description
Distributed as aqueous solution. Colorless to slightly yellow aqueous solution.
Uses
Intravenous injection contrast medium for magnetic resonance imaging.

Registry Numbers and Inventories.
CAS
120066-54-8
RTECS
LW4430000
Merck
12,4348

Properties.
Formula
C17H29GdN4O7
Formula mass
558.69
Vapor pressure, mmHg
1.6E-7 (26 C)
Solubility in water
Very soluble
Partition coefficient, pKow
-3.57

Hazards and Protection.
Storage
Store at 20-25 degrees C. Protect from light and do not freeze.
Protection
Lab coat, impermeable gloves (latex or nitrile) and eye protection should be worn as a minimum precaution.
Respirators
Not necessary for normal clinical environment. Non-routine exposure conditions may require NIOSH approved respiratory protection appropriate for exposure potential. Self-contained breathing apparatus should be available for emergency use.
Small spills/leaks
Absorb spill with inert material, e.g. sand, vermiculite or other non-combustible absorbent materials, and place into a closed container for reclamation or disposal. The spill area should be ventilated and decontaminated after material has been picked up.
Stability
Stable under normal conditions.
Incompatibilities
Acids.
Decomposition
Carbon monoxide, carbon dioxide, nitrogen oxides.

Fire.
Fire fighting
In case of fire, flood with water. Firefighters should wear self-contained breathing apparatus, flame and chemical resistant clothing, boots and gloves. Evacuate personnel to an upwind direction, remove unneeded material and cool container(s) with water from a maximum distance.
Combustion products
Carbon monoxide, carbon dioxide, nitrous oxides.

Health.
Exposure effects
   Ingestion
Ingestion of large quantities of this material in an occupational setting would not be expected to occur. Ingestion of trace amounts of the material might occur if the material contacts hands and hands are not washed prior to eating, drinking or smoking. The extent of systemic absorption of gadoteridol after ingestion is not known.
   Inhalation
Under normal conditions, exposure to this material by inhalation is not expected to occur.
   Skin
Exposure may occur via skin contact if gloves and protective clothing are not worn. The extent of systemic absorption of the material after skin contact is not known.

First aid
 
   Ingestion
Get medical attention immediately. Vomiting may be induced if a person is conscious and if ingestion has occurred within the past three hours. Never induce vomiting in a person who is unconscious or experiencing convulsions.
   Inhalation
Remove exposed person to fresh air. If person is not breathing, give artificial respiration. If breathing is difficult administer oxygen. Get medical attention immediately.
   Skin
Remove contaminated clothing. Wash skin with plenty of water for 5 minutes. Seek medical attention if irritation (redness, itching or swelling) develops or persists.
   Eyes
Hold eyelids apart and flush with plenty of water for 5 minutes. Get medical attention if signs of irritation develop.

Transport.