Ganaxolone

  • 3a-Hydroxy-3b-methyl-5a-pregnan-20-one
  • Pregnan-20-one, 3-hydroxy-3-methyl-, (3a,5a)-
Formula
C22H36O2
Structure
Description
White solid.
Uses
Antisiezure agent.

Registry Numbers and Inventories.
CAS
38398-32-2
22 24/25
RTECS
TU4384700
Merck
12,10486

Properties.
Formula
C22H36O2
Formula mass
332.53
Melting point, °C
190 - 192
Boiling point, °C
435
Vapor pressure, mmHg
2.2E-9 (25 C)
Density
1.04 g/cm3 (20 C)
Solubility in water
1.1mg/L (25 C)
pKa/pKb
15.18 (pKa)
Partition coefficient, pKow
5.43
Heat of vaporization
79.77 kJ/mol

Hazards and Protection.
Storage
Store at 2 - 8 C. Keep container tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.
Respirators
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable if stored as directed.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
185
Fire fighting
Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Causes drowsiness and sedation.
   Ingestion
May be harmful if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.