Genistein

  • 4',5,7-Trihydroxyisoflavone
  • 5,7,4'-Trihydroxyisoflavone
  • Baichanin A
  • C.I. 75610
  • Sophoricol
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
Formula
C15H10O5
Structure
Description
odorless yellow-white powder
Uses
Chemical probe to explore signal transduction pathways.

Registry Numbers and Inventories.
CAS
446-72-0
EC (EINECS/ELINCS)
207-174-9
R 36/37/38
RTECS
NR2392000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
13,4402
Beilstein/Gmelin
263823
Beilstein Reference
5-18-04-00594
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed

Properties.
Formula
C15H10O5
Formula mass
270.24
Melting point, °C
297-298
Solubility in water
Insoluble
pKa/pKb
7.08 (pKa)
Partition coefficient, pKow
2.84

Hazards and Protection.
Storage
Store in a tightly closed container. Refrigerator (approx 4 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin. May cause allergic dermatitis called nickel itch. Symptoms may include burns and ulceration of skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.