Gesemine hydrochloride

Formula
C20H22N2O2 . HCl
Uses
Medication. Formerly used as central stimulant, tool in neurological research.

Registry Numbers and Inventories.
CAS
35306-33-3
EC (EINECS/ELINCS)
252-504-7
RTECS
LX9150000
RTECS class
Other
Beilstein/Gmelin
5406577
Beilstein Reference
4-27-00-07526

Properties.
Formula
C20H22N2O2.ClH
Formula mass
358.90
Melting point, °C
326
Density
1.37 g/cm3
Solubility in water
Soluble

Hazards and Protection.

Fire.

Health.
Exposure effects
Effects of poisoning include headache, dizziness, dry mouth, sweating, muscular weakness or rigidity seizures, dyspnea, and bradycardia.
   Inhalation
Dyspnea may occur. Death is due to failure of respiratory musculature. Dizziness and headaches may occur. In severe poisonings there may be a rare seizure.
   Skin
Dermatitis has been reported after handling the leaves flowers, and roots.
   Eyes
Mydriasis, ptosis (due to muscle weakness), diplopia and visual loss may be seen with poisonings.

First aid
 
   Ingestion
Consider gastric lavage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Administer charcoal as a slurry 240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old. Immediate dilution with milk or water may be of benefit in caustic or irritant chemical ingestions.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.