Glybenclamide

  • Glyburide
  • N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
  • 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
Formula
C23H28ClN3O5S
Structure
Description
white solid
Uses
Hypoglycemic drug.

Registry Numbers and Inventories.
CAS
10238-21-8
EC (EINECS/ELINCS)
233-570-6
RTECS
YS4725200
RTECS class
Drug; Reproductive Effector; Human Data
Merck
13,4491
Beilstein/Gmelin
2230085
Beilstein Reference
6-14
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C23H28ClN3O5S
Formula mass
494.01
Melting point, °C
168 - 172
Density
1.38 g/cm3
Solubility in water
1.1 mg/L (37 C)

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Protective gloves. Chemical safety goggles.
Respirators
Wear dust mask.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation. Target organ(s): Pancreas. G.I. System.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.