Glycerol alpha-monochlorohydrin

  • alpha-Chlorohydrin
  • 3-Chloro-1,2-propanediol
  • 3-Chloro-1,3-dihydroxypropane
  • 3-Chloropropylene glycol
  • 3-Chloropropane-1,2-diol
Formula
ClCH2CH(OH)CH2OH
Structure
Description
A colorless liquid.
Uses
To lower the freezing pointermediate of dynamite, in the manufacture of dye intermediates, as a rodent chemosterilant.

Registry Numbers and Inventories.
CAS
96-24-2
EC (EINECS/ELINCS)
202-492-4
EC Class
toxic
R 23/24/25 37/38 41
S 26 36/37/39 45
RTECS
TY4025000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2689
Merck
13,2164
Beilstein/Gmelin
635684
Beilstein Reference
4-01-00-02484
EPA OPP
117101
Swiss Giftliste 1
G-1405
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H7ClO2
Formula mass
110.54
Melting point, °C
-40
Boiling point, °C
213
Vapor pressure, mmHg
0.04 (25 C)
Vapor density (air=1)
1.322
Density
1.338 g/cm3 (0 C)
Solubility in water
Very soluble
Viscosity
159.00 cp (20 C)
Refractive index
1.4783 (20 C)
pKa/pKb
13.22 (pKa)
Partition coefficient, pKow
-0.76
Heat of vaporization
52.3 kJ/mol

Hazards and Protection.
Storage
Do not store in direct sunlight. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Keep container tightly closed. Avoid contact with heat, sparks and flame. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, chlorine, carbon monoxide, carbon dioxide, chloride fumes.

Fire.
Flash Point,°C
113
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
May burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. May polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
2
Exposure effects
Chronic ingestion may cause liver damage.
   Ingestion
May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.
UN number
2689
Response guide
Hazard class
6.1
Packing Group
III
 
HS Code
2905 59 99
 
Std. Transport #
4925183