Glycolonitrile, acetate

  • Acetic acid cyanomethyl ester
  • Cyanomethyl acetate
  • Acetoxymethyl cyanide
  • Acetoxyacetonitrile
Formula
C4H5NO2
Structure
Uses
Manufacture intermediates in the production oof pharmaceuticals & as component of synthetic resins glycolonitrile.

Registry Numbers and Inventories.
CAS
1001-55-4
RTECS
MC7700000
RTECS class
Other
Beilstein/Gmelin
1745113
Beilstein Reference
3-03-00-00401
Swiss Giftliste 1
G-4177

Properties.
Formula
C4H5NO2
Formula mass
99.10
Boiling point, °C
177
Density
1.103 g/cm3 (20 C)
Solubility in water
Very soluble
Refractive index
1.4106 (20 C)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
While there are no reports of injury to humans handling the material, care should be used to avoid skin contact and inhalation of vapor, especially heated vapor. Methyl cyanoacetate.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
2
Exposure effects
   Ingestion
Anorexia may be noted in patients exposed chronically, while nausea and vomiting are seen in acute exposures. Vomiting has preceded serious toxicity within several hours in most cases of ingestion.
   Inhalation
Hyperpnea, respiratory insufficiency, kussmaul respirations, and chest tightness have been reported.
   Skin
Splash contact with the liquid may cause faint erythema of short duration. Chronic exposure may produce maculopapular vesicular dermatitis.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.