- Acetic acid cyanomethyl ester
- Cyanomethyl acetate
- Acetoxymethyl cyanide
Manufacture intermediates in the production oof pharmaceuticals & as component of synthetic resins glycolonitrile.
Registry Numbers and Inventories.
Swiss Giftliste 1
Boiling point, °C
1.103 g/cm3 (20 C)
Solubility in water
1.4106 (20 C)
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
While there are no reports of injury to humans handling the material, care should be used to avoid skin contact and inhalation of vapor, especially heated vapor. Methyl cyanoacetate.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Anorexia may be noted in patients exposed chronically, while nausea and vomiting are seen in acute exposures. Vomiting has preceded serious toxicity within several hours in most cases of ingestion.
Hyperpnea, respiratory insufficiency, kussmaul respirations, and chest tightness have been reported.
Splash contact with the liquid may cause faint erythema of short duration. Chronic exposure may produce maculopapular vesicular dermatitis.
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.