(+)-Griseofulvin

  • Sporostatin
  • Polygris
  • Amudane
  • Fulvistatin
  • Xuanjing
  • 7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
Formula
C17H17ClO6
Structure
Description
White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless.
Uses
Medication, fungicide.

Registry Numbers and Inventories.
CAS
126-07-8
EC (EINECS/ELINCS)
204-767-4
RTECS
WG9800000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product
Merck
12,4571
Beilstein/Gmelin
95226
Beilstein Reference
5-18-05-00150
EPA OPP
471400
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C17H17ClO6
Formula mass
352.77
Melting point, °C
218 - 222
Boiling point, °C
570
Vapor pressure, mmHg
5E-13 (25 C)
Density
1.4 g/cm3
Solubility in water
Insoluble
Partition coefficient, pKow
2.36
Heat of fusion
39.4 kJ/mol
Heat of vaporization
85.6 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
228
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.

Health.
Exposure limit(s)
OSHA: Possible Select carcinogen
Carcinogin
I-2B, CP65
Exposure effects
headache, dizziness, disorientation, lethargy, fatigue, and mental confusion may be noted. Paresthesia secondary to peripheral neuropathy has been reported following therapeutic use. Use in pregnancy is contraindicated. Griseofulvin is classified as FDA pregnancy category C. There is no data concerning breast milk.
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound may include urticaria, headaches, confusion, dizziness, nausea, diarrhea, photosensitivity and leukopenia. Other symptoms may include epigastric distress, fever and arthralgia. It may cause renal damage and porphyria. It may also cause peripheral neuritis, syncope and blurred vision. Exposure has caused skin rashes, fatigue, proteinuria and, rarely, angioneurotic edema, paresthesia and lupus erythematosus. Symptoms may include dryness of the mouth, an altered sensation of taste, gastrointestinal disturbances, severe allergic reactions, erythema multiforme, exfoliative dermatitis, candidiasis, depression, irritability and, rarely, hepatitis.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Transport.