Guanine

  • 2-Amino-1,7-dihydro-6H-purin-6-one
  • 2-Aminohypoxanthine
Formula
C5H5N5O
Structure
Description
White powder.
Uses
Biochemical research, cosmetics.

Registry Numbers and Inventories.
CAS
73-40-5
EC (EINECS/ELINCS)
200-799-8
R 36/37/38
RTECS
MF8260000
RTECS class
Tumorigen; Mutagen
Merck
13,4580
Beilstein/Gmelin
9680
Beilstein Reference
4-26-00-03890
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H5N5O
Formula mass
151.13
Melting point, °C
>220
Boiling point, °C
Sublimes
Density
1.67 g/cm3
Solubility in water
Very soluble
pKa/pKb
9.40 (pKa)
Partition coefficient, pKow
-0.90
Heat of combustion
-2499 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Animal studies have reported the development of tumors.
   Ingestion
May be harmful if swallowed.
   Inhalation
Causes respiratory tract irritation. May be harmful if inhaled. Causes irritation of the mucous membrane and upper respiratory tract.
   Skin
Causes skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.