Guthion

  • Azinphos-methyl
  • Phosphorodithioic acid O,O-dimethyl S-((4-oxo-11,2,3-benzotriazin-3-(4H)-yl)methyl) ester
  • S-3,4-dihydro-4-oxo-1,2,3-Benzotriazin-3-ylmethyl) O,O-dimethyl phosphorodithioate
Formula
C10H12N3O3PS2
Structure
Description
It is a wettable powder.
Uses
Nonsystemic insecticide and acaricide.

Registry Numbers and Inventories.
CAS
86-50-0
EC (EINECS/ELINCS)
201-676-1
EC Index Number
015-039-00-9
EC Class
Very toxic; Toxic; Sensitising; Dangerous for the Environment
RTECS
TE1925000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
2783
Merck
12,944
Beilstein/Gmelin
280476
Beilstein Reference
4-26-00-00460
EPA OPP
58001
Swiss Giftliste 1
G-1200
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C10H12N3O3PS2
Formula mass
317.33
Melting point, °C
73
Boiling point, °C
401
Vapor pressure, mmHg
1.2E-6 (25 C)
Odor Threshold Odor threshold 0.0002 mg/kg water
Density
1.44 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.6115 (20 C)
Partition coefficient, pKow
2.75
Heat of vaporization
65.1 kJ/mol
Heat of combustion
-6277 kJ/mol

Hazards and Protection.
Storage
Keep in well ventilated area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate chemical protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus.
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Water spill: If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
Stability
Stable.
Incompatibilities
Contact with strong oxidizers may cause fires and explosions. Incompatible with alkaline materials. Avoid contact with strong oxidizers, acids.
Decomposition
Decomposes at elevated temperatures. When heated to decomposition it emits very toxic fumes of phosphoxides, sulfoxides and oxides of nitrogen.

Fire.
Flash Point,°C
196
Fire fighting
Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.
Fire potential
Nonflammable.
Hazards
Some of the formulations may burn, but none of them ignite easily. Container may explode in the heat of the fire. Rapidly hydrolyzed by cold alkali or cold acid. Unstable at temperatures above 390F.
Combustion products
Hazardous decomposition products: Toxic gases and vapors (such as sulfur dioxide, oxides of nitrogen, phosphoric acid mist, and carbon monoxide) may be released from a fire involving azinphos methyl.

Health.
Exposure limit(s)
TLV: ppm; 0.2 mg/m3 (skin) (ACGIH 1997). MAK: ppm; 0.2 mg/m3; III, H (1996). OSHA PEL: TWA 0.2 mg/m3 skin NIOSH REL: TWA 0.2 mg/m3 skin NIOSH IDLH: 10 mg/m3
Poison_Class
2
Exposure effects
Fever, low heart rate and abnormally low blood pressure, or rapid heart rate and elevated blood pressure may occur. Headache, dizziness, muscle spasms and profound weakness are common. Alterations of level of consciousness, anxiety, paralysis, seizures and coma may occur. Seizures may be more common in children.
   Ingestion
Vomiting, hypersalivation, diarrhea, fecal incontinence and abdominal pain may occur.
   Inhalation
Dyspnea, rales, bronchorrhea, bronchospasm, or tachypnea may be noted. Noncardiogenic pulmonary edema may occur in severe cases. Chemical pneumonitis may be seen.
   Skin
Sweating is a consistent but not universal sign.
   Eyes
Constriction of the pupil, tearing, and blurred vision are common. Prolonged dialation of the pupils may occur in severe poisonings. Opsoclonus has been reported in one case. Salivation commonly occurs.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and jewelry. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
2783
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
AZM
 
Std. Transport #
4921526