gamma-Butyrolactone

  • Butyric acid lactone
  • 1,4-Lactone
  • gamma-Lactone
  • Tetrahydro-2-furanond dihydro-2(3H)-furanone.
  • 1,2-Butanolide
  • 1,4-Butanolide
Formula
C4H6O2
Structure
Description
Oily liquid. Pleasant odor.
Uses
Intermediate in synth of polyvinylpyrrolidone, dl-methionine, piperidine, phenylbutyric acid, thiobutyric acids, solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene, constituent of paintermediate removers, textile aids, drilling oils.

Registry Numbers and Inventories.
CAS
96-48-0
EC (EINECS/ELINCS)
202-509-5
EC Class
harmful, irritant
R 22 36
RTECS
LU3500000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Primary Irritant
Merck
13,1596
Beilstein/Gmelin
105248
Beilstein Reference
5-17-09-00007
Swiss Giftliste 1
G-4893
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H6O2
Formula mass
86.09
Melting point, °C
-44
Boiling point, °C
204
Vapor pressure, mmHg
3.2 (25 C)
Vapor density (air=1)
3
Critical temperature
458
Critical pressure
50.6
Density
1.1286 g/cm3 (20 C)
Solubility in water
Very soluble
Viscosity
1.738 cp (25 C)
Surface tension
43.44 g/s2 (25 C)
Refractive index
1.4348 (20 C)
Dielectric constant
39 (25 C)
Partition coefficient, pKow
-0.64
Heat of fusion
9.57 kJ/mol
Heat of vaporization
54.4 kJ/mol
Heat of combustion
-2011 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong acids - strong bases - strong reducing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
100-101
Autoignition, °C
455
Upper exp. limit, %
15.6
Lower exp. limit, %
2.7
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This chemical is combustible.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
4
Exposure effects
Significant respiratory depression may occur in comatose patients. Low heart rate with increases or decreases in blood pressure may be anticipated. the primary effect is dose-related CNS depression; amnesia and hypotonia after 10 mg/kg, somnolence, drowsiness, dizziness, and euphoria after 20 to 30 mg/kg, and coma after 50 to 70 mg/kg.
   Ingestion
May cause digestive tract disturbances. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
USCG CHRIS Code
BLA
 
HS Code
2932 29 80
 
IMO Chemical Code
18
IMO Pollution Category
D