Halobetasol propionate

  • Ulobetasol propionate
  • Ultravate
  • Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6-alpha,11-beta,16-beta)
Formula
C25H31ClF2O5
Structure
Description
Distributed as 0.05% ointment.
Uses
Topical corticosteroid.

Registry Numbers and Inventories.
CAS
66852-54-8
RTECS
TU3723500
Merck
12,4625

Properties.
Formula
C25H31ClF2O5
Formula mass
484.97
Melting point, °C
220 - 221
Vapor pressure, mmHg
2.1E-15 (25 C)
Density
1.31 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
12.58 (pKa)
Partition coefficient, pKow
3.73

Hazards and Protection.
Storage
Product should be stored in cool, dry place, away from sources of heat. Store between 15 and 30 C.
Small spills/leaks
Assure slippery conditions are nullified. Add sand or dirt. Scoop up and remove to plastic-lined fiber containers immediately. Dispose of in accordance with federal, state and local regulations.
Stability
stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents, bases.

Fire.
Fire fighting
Extinguishing agents: Water, Carbon Dioxide, Dry Chemical, Foam. Wear self-contained breathing apparatus.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
May cause irritation of skin and eyes. May cause mutagen and reproductive effects. May cause suppression of HPA axis, gastrointestinal upset and temporary CNS depression. Kidney disorders, hypersensitivity to any of the components.

First aid
 
   Ingestion
Give 2-4 cups of milk or water to dilute. Never give anything by mouth to an unconscious person.
   Inhalation
Not applicable with normal use. In cases of overexposure, remove to fresh air. If breathing is difficult, give oxygen. If breathing has stopped, give artificial respiration. Contact a physician.
   Skin
Wash immediately and thoroughly with soap and water. If redness, itching or burning sensation develops, get medical attention.
   Eyes
Flush immediately with plenty of water for at least 15 minutes.

Transport.