Halothane

  • 2-Bromo-2-chloro-1,1,1-trifluoroethane
  • 1-Bromo-1-chloro-2,2,2-trifluoroethane
  • 1,1,1-Trifluoro-2-Bromo-2-chloroethane
  • 2,2,2-Trifluoro-1-Bromo-1-chloroethane
Formula
CF3CHClBr
Structure
Description
Clear colorless highly volatile liquid with a sweet chloroform-like odor.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
151-67-7
EC (EINECS/ELINCS)
205-796-5
R 36 40
S 26 36/37/39
RTECS
KH6550000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
1610
Merck
13,4619
Beilstein/Gmelin
1736947
Beilstein Reference
4-01-00-00156
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2HBrClF3
Formula mass
197.38
Boiling point, °C
50.2
Vapor pressure, mmHg
753 (50 C)
Vapor density (air=1)
6.9
Density
1.86 g/cm3
Solubility in water
3 g/L
Refractive index
1.3696 (20 C)
Partition coefficient, pKow
2.30
Heat of vaporization
29.56 kJ/mol
Heat of combustion
-762 kJ/mol

Hazards and Protection.
Storage
Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a tight, light resistant container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Sensitive to light, may be stabilized with 0.01% Thymol.
Incompatibilities
Sensitive to exposure to light Incompatible with oxidizing materials It

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
Fire potential
This material is nonflammable
Hazards
Containers may explode when heated.
Combustion products
All fluorocarbons will undergo thermal decomposition when exposed to flame or red-hot metal.Decomposition products of the chlorofluorocarbons will include hydrofluoric and hydrochloric acid along with smaller amounts of phosgene and carbonyl fluoride.

Health.
Exposure limit(s)
TLV: 50 ppm; 404 mg/m3 (ACGIH 1992-1993). PDK: 20 mg/m3 C (USSR 1993). NIOSH REL: C 2 ppm (16.2 mg/m3) 60-minute *Note: REL for exposure to waste anesthetic gas.
Exposure effects
Primary toxic effects include abnormally low blood pressure, low heart rate, and respiratory depression. With therapeutic use - 1. Malignant elevated body temperature is a rare complication of halothane anesthesia. Coma may occur after ingestion or injection.
   Ingestion
Vomiting may occur after halothane ingestion.
   Inhalation
Inhalation of vapors or dust is extremely irritating. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful.
   Skin
An acneiform eruption due to hypersensitivity was reported in one patient occupationally exposed to halothane.
   Eyes
Mydriasis was reported in one comatose patient after ingestion of 250 mL. Prolonged dialation of the pupils was not thought to be due to anoxia. Halothane has been reported to lower intraocular pressure.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1610
Response guide
Hazard class
6.1