Heparin

  • Depo heparin
  • HED heparin
  • alpha-Heparin
  • Heparinate
  • Heparinic acid
  • Heparin sulfate
Formula
Unspecified
Description
White or pale-colored amorphous powder. Nearly odorless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
9005-49-6
EC (EINECS/ELINCS)
232-681-7
RTECS
MI0700000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
Beilstein/Gmelin
NA
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Solubility in water
soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Hygroscopic; ampuled solution may be stored @ room temperature for at least 12 mo sodium salt.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
hallucinations and distorted perceptions may occur. Intracerebral hemorrhage has been reported. Compressive neuropathy may occur. Reports of increased rates of abnormal pregnancies and fetal outcomes can be due to maternal co-morbidities. <br>Heparin is classified as Pregnancy Category C.
   Ingestion
Hemothorax may occur. Pulmonary edema and/or embolism have been reported.
   Inhalation
Hemothorax may occur. Pulmonary edema and/or embolism have been reported.
   Skin
Hematoma and ecchymoses have been frequently noted especially with intramuscular injections. Skin necrosis is common with subcutaneous heparin injections; dermatitis, eczema, and generalized urticaria have been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Orally ingested heparin is not absorbed from the gastrointestinal tract and will not result in toxicity. Refer to the parenteral exposure section for treatment recommendations following toxic parenteral exposures.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.