Hesperidine

  • Hesperetin 7-rhamnoglucoside
  • Hesperetin 7-rutinoside
  • Cirantin
  • 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-
Formula
C28H34O15
Structure
Description
Amorphous, light brown solid.
Uses
Natural product food supplement.

Registry Numbers and Inventories.
CAS
520-26-3
EC (EINECS/ELINCS)
208-288-1
RTECS
MK6650000
RTECS class
Other
Merck
12,4705
Beilstein/Gmelin
75140
Beilstein Reference
5-18-05-00218
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C28H34O15
Formula mass
610.57
Melting point, °C
260
Boiling point, °C
930
Vapor pressure, mmHg
1E-37
Vapor density (air=1)
5.8
Solubility in water
20 mg/L
pKa/pKb
7.15 (pKa)
Partition coefficient, pKow
1.18
Heat of vaporization
141.7

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Cover with dry earth, dry sand, or other non-combustible material followed with plastic sheet to minimize spreading and contact with water.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong bases - strong reducing agents.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Flash Point,°C
306
Autoignition, °C
336
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Water or foam may cause frothing.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause severe eye irritation and possible injury.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.