Hexamethylene diisocyanate

  • Hexamethylene di-isocyanate
  • 1,6-Diisocyanatohexane
  • 1,6-Hexamethylene diisocyanate
  • Hexamethylene-1,6-diisocyanate
  • HMDI
Formula
C8H12N2O2
Structure
Description
Colorless to slightly yellow liquid with a sharp, pungent odor.
Uses
Component of polyurethane elastomers, coatings.

Registry Numbers and Inventories.
CAS
822-06-0
EC (EINECS/ELINCS)
212-485-8
EC Index Number
615-011-00-1
EC Class
Toxic; Irritant; Sensitising
R 23 36/37/38 42/43
S 26 28.1 38 45
RTECS
MO1740000
RTECS class
Agricultural Chemical and Pesticide
UN (DOT)
2281
Beilstein/Gmelin
956709
Beilstein Reference
4-04-00-01349
Swiss Giftliste 1
G-3606
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H12N2O2
Formula mass
168.20
Melting point, °C
-67
Boiling point, °C
255
Vapor pressure, mmHg
0.05
Vapor density (air=1)
5.81
Saturation Concentration
Approximately 66 ppm at 25 C (calculated)
Odor Threshold Odor threshold 0.001 ppm
Density
0.972 g/cm3 (15 C)
Solubility in water
Reacts
Refractive index
1.45067 (20 C)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.
D1A D2A D2B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Do not allow contact with water. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not get water on spilled substances or inside containers. Cover with dry earth, dry sand, or other non-combustible material followed with plastic sheet to minimize spreading and contact with water.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Polymerization may occur upon heating.
Incompatibilities
Strong oxidizing agents, strong bases, alcohols, amines, heat, moisture, water, carboxylic acids, organotin catalysts.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
130
Autoignition, °C
454
Upper exp. limit, %
9.5
Lower exp. limit, %
0.9
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Fire or excessive heat may result in violent rupture of the container due to bulk polymerization. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Most foams will react with the material and release corrosive/toxic gases. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
May burn but does not ignite readily.
Hazards
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NOISH: 0.005 ppm TWA; 0.035 mg/m3 TWA
Poison_Class
2
Exposure effects
Chronic inhalation may cause effects similar to those of acute inhalation. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. Prolonged or repeated exposure may cause lung irritation, chest pain, and pulmonary edema. Chronic overexposure to isocyanates has been reported to cause lung damage, including decreased lung fuction, which may be permanent.
   Ingestion
May cause irritation of the digestive tract. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
   Inhalation
May cause asthmatic attacks due to allergic sensitization of the respiratory tract. Causes irritation of mucous membrane. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Exposure to low and often even unmeasurable isocyanate concentration results in sensitization. Symptoms of exposure include: increased secretions, cough, pain or respiration, Symptoms of initial exposure may include nocturnal dyspnea with nocturnal cough with progression to asthmatic bronchitis.
   Skin
Causes severe skin irritation. Harmful if absorbed through the skin. If absorbed, causes symptoms similar to those of ingestion.
   Eyes
Causes severe eye irritation. Lachrymator. Vapors may cause reversible corneal epithelial edema with impairing of vision.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2281
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
HMS, HDI
 
HS Code
2929 10 90
 
Std. Transport #
4921579
 
IMO Chemical Code
17
IMO Pollution Category
B
IMO Hazard code
S/P