Hexamethylphosphoric triamide

  • Hexamethylphosphoramide
  • Hexamethylphosphamide
  • HMPA
Formula
[(CH3)2N]3PO
Structure
Description
Clear colorless to light amber liquid with a spicy odor.
Uses
Processing solvent for aromatic polyamide fiber. chemosterilant.

Registry Numbers and Inventories.
CAS
680-31-9
EC (EINECS/ELINCS)
211-653-8
EC Index Number
015-106-00-2
EC Class
Carcinogenic Category 2; Mutagenic Category 2
RTECS
TD0875000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2810
Merck
12,4761
Beilstein/Gmelin
1099903
Beilstein Reference
4-13-00-00364
Swiss Giftliste 1
G-3310
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H18N3OP
Formula mass
179.2
Melting point, °C
7.2
Boiling point, °C
235
Vapor pressure, mmHg
0.03 (25 C)
Vapor density (air=1)
6.18
Density
1.026 g/cm3 (20 C)
Solubility in water
Miscible
Viscosity
3.4 cp (25 C)
Refractive index
1.4572 (20 C)
pKa/pKb
5.30 (PKB)
Partition coefficient, pKow
0.29
Heat of fusion
10.8 kJ/mol
Heat of vaporization
45.1 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
106
Autoignition, °C
230
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: ppm; mg/m3 A2 (skin) (ACGIH 1993). NIOSH REL: Ca See Appendix A
Carcinogin
G-A3, I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
Possible cancer hazard based on tests with laboratory animals. May cause cancer in humans.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
HMP