Hydrastine

  • beta-Hydrastine
  • l-Hydrastine
  • (-)-Hydrastine
  • (1R,9S)-(-)-b-Hydrastine
  • 6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)phthalide
Formula
C21H21NO6
Structure
Description
A phthalide isoquinoline alkaloid, isolated from Corydalis stricta.
Uses
Weak antiseptic that may help to combat bacteria-induced diarrhea.

Registry Numbers and Inventories.
CAS
118-08-1
EC (EINECS/ELINCS)
204-233-0
20/21/22
RTECS
MU6030000
RTECS class
Drug
Merck
12,4806
Beilstein/Gmelin
98575
Beilstein Reference
4-27-00-06833
Austrailia AICS
Listed

Properties.
Formula
C21H21NO6
Formula mass
383.4
Solubility in water
Insoluble
pKa/pKb
7.03 (pKb)
Heat of vaporization
82.9 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at -20 C
Protection
Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
286
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Harmful by inhalation, in contact with skin and if swallowed. Target organ(s): Central nervous system.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.