Hydrocortisone

  • ala-cort
  • cobadex
  • Cort-Dome
  • Corticreme
  • Cortifan
  • Cortifoam
Formula
C21H30O5
Structure
Description
Plates from alc or iso-propyl alc. Odorless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
50-23-7
EC (EINECS/ELINCS)
200-020-1
RTECS
GM8925000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
1325
Merck
12,4828
Beilstein/Gmelin
1354819
Beilstein Reference
4-08-00-03422
EPA OPP
6312
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C21H30O5
Formula mass
362.47
Melting point, °C
202 - 204
Boiling point, °C
567
Vapor pressure, mmHg
3E-15 (25 C)
Density
1.4 g/cm3
Solubility in water
0.28 mg/ml@ 25 deg
pKa/pKb
12.48
Partition coefficient, pKow
1.43
Heat of fusion
31.0 kJ/mol
Heat of vaporization
97.7 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Make no contact with the spilled material. ELIMINATE all ignition sources and ground all equipment. With clean shovel place material into clean, dry container and cover loosely; move containers from spill area.
Stability
Sensitive to light very stable @ room temperature except in presence of alkalis or strong acids.

Fire.
Flash Point,°C
310
Fire fighting
Small Fires: Dry chemical, carbon dioxide, sand, earth, water spray or regular foam. Large Fires: Water spray, fog or regular foam.
Fire potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Exposure effects
seizures have been reported following pulse methylprednisolone therapy.
   Ingestion
Intractable hiccups have been reported following high-dose oral dexamethasone therapy. Gastrointestinal perforation was reported, in premature infants, following high-dose dexamethasone administration.
   Skin
May cause burns.
   Eyes
See Skin.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush with running water for at least 20 minutes. Wash skin with soap and water.
   Eyes
In case of contact with substance, immediately flush with running water for at least 20 minutes.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III